Masane is the latest in a long line of female bearers of the Witchblade, an arcane and ancient weapon of unthinkable power. Conscripted into the service of the Doji Group, she is charged with destroying X-Cons, a murderous scourge of mysterious origin stalking the streets of Tokyo.

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  Precocious Rihoko is Masane's young daughter, and it times she seems like the only member of the family with any sense.

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  Takayama is the stoic and shrewd Director of the Special Machines Division at Doji Group Industries. He leads his company in the pursuit of understanding and controlling the Witchblade, and his career is one of cut-throat corporate intrigue.

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  Tozawa is a freelance photographer who is always right in the middle of the action. His affection for Masane and Rihoko runs deep.

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  Segawa is the right hand man of Takayama, and his loyalty to those that wield real power is firm and true.

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  Reina is a specialist on the NSWF Cloneblade team; not only an intelligent researcher, but also as a fierce warrior known as Lady.

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  Father is the Founder and Chairman of NSWF and has a long standing interest in the Witchblade. He delves deep into twisted and unethical science to further his goals.