The second season marks an eclectic line-up of guests ranging from William Shatner to Marilyn Manson, and provides viewers with a unique environment for electrifying musical performances ranging from The Stooges to Peaches' television debut.

The Henry Rollins Show takes a straightforward approach to late-night talk. With one guest and one musical performance per week, Rollins engages guests such as Ben Stiller and John Waters in raw discussions on politics, world affairs, religion and pop culture. New this season, writer, actress and comedian Janeane Garofalo offers special commentary from her New York City apartment in a segment called The Disquisition.

At "The Bombshelter" recording studio, the Los Angeles based studio where Rollins' musical performances tape, artists such as Ryan Adams and The Mars Volta are given the freedom to perform outside of the restrictions of the usual three-minute time slot that is common on most late night shows. Each artist performs two songs: one for the episode and one featured on IFC.com.